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Treatment of type 2 diabetes


The use of cell therapy will help increase tissue sensitivity to insulin and reduce the use of insulin-containing drugs.

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It is possible to improve the quality of life!

About 67% of patients have a positive response to the treatment that improves the course of the disease, reduces insulin doses, or even seizes the need for insulin-containing drugs.

Roman Sulik, MD, coordinator of cell therapy programs, neurologist of the highest qualification category, and Candidate of Medical Sciences.

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Which types of stem cells are used?

Type 2 diabetes is a chronic disease that can have severe consequences to the body if not controlled and improved.
Currently, the main goal in the treatment of type 2 diabetes is to improve the sensitivity (reduction of insulin resistance) of peripheral tissues to insulin and promote its synthesis and secretion.
The GOOD CELLS team offers cell therapy that will help you improve the course of the disease, reduce the use of insulin-containing drugs, or cancel them altogether. We also deal with complications such as diabetic foot, diabetic cardiomyopathy, diabetic gastroenteropathy, erectile dysfunction, etc. Thus, there is a real opportunity to improve the quality of life and increase self-confidence.
The results can be observed during the first two weeks. They are due to the so-called paracrine component of the stem cells. After entering the human body, stem cells begin to secrete specific signaling molecules, proteins, to which the immune system, peripheral organs, and tissues respond and start rebuilding as a part of this treatment. More stable results of stem cell-based treatment can be observed during an average of three months after therapy.

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For whom is this treatment?

Indications:
This treatment is indicated to patients over 18 y.o. with confirmed type 2 diabetes mellitus, regardless of its stage and complications.
Contraindications:
cancer, or the history of it in the last 5 years; pregnancy; mental disorders and psychological instability; alcohol and drug addiction.

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Which types of stem cells are used?

The physician may suggest the use of different cell types depending on the character of the disease, namely the extent and profile of the complications present in the patient, and according to which target organs are damaged and to what extent.
The main stem cells type for the treatment of type II diabetes are mesenchymal stem cells from adipose tissue (MSCs of adipose tissue), which increase tissue sensitivity to insulin, and as a result, there is a decrease in dosage, improved course of the disease, reduced rate and degree of progression. In addition, stem cell therapy, due to its positive effect on vascular endothelium, improves blood supply to internal organs, microcirculation, and metabolic processes in tissues, which reduces the number of complications of diabetes.

The use of neural crest-derived multipotent stem cells helps to improve reinnervation, regulation of internal organs, autonomic nervous system, which is necessary for diabetes because the violation of these processes leads to serious complications.
In addition, the physician may prescribe additional administration of multipotent umbilical cord mesenchymal stem cells (MSCs), which have a higher proliferation potential, stable doubling time over a number of passages, a high frequency of colony-forming cells, a wide potential for differentiation, and low immunogenicity. Umbilical cord MSCs have been shown to reduce tissue resistance to insulin, which is related to the anti-inflammatory activity of cells.
In combination, these types of stem cell-based therapy can have a positive effect on the course of diabetes, reducing the number and dosage of drugs, reducing the risk of complications, restoring dysfunction of organs and tissues.

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The treatment process

1

Consultation with a manager

Contact our managers with no obligations on your side. At this step, we gather your medical information and confirm the diagnosis. After that, we'll arrange a free online or offline consultation with a doctor.

2

Online/offline consultation with a doctor 

A personal consultation with a doctor is an excellent opportunity for you to find out all details of the program and get an individual prognosis. All the medical information you provide will be carefully reviewed so that you get the most effective treatment. The procedures take place in our clinical institutions in Kyiv, Ukraine. The course of the treatment is developed individually and lasts between 1 and 7 days.

3

Checkup

During the checkup, the doctor assesses your readiness for cell therapy. If the assessment is positive, biological materials are taken. Depending on your doctor's recommendations, you may be prescribed your own* or donor stem cells.
*If you are prescribed the treatment with your own cells, you will have an ear punch biopsy performed under anesthesia in an operating room. The procedure lasts for 15 minutes. The punch depth is up to 4 mm, and the diameter is up to 3 mm.

4

Preparation of the stem cell product

OWN CELLSAfter the biomaterials are collected, our team of biotechnologists will prepare a therapeutic dose of stem cells. In our laboratory, we will select stem cells from your sample, grow the required number of cells, test them, then create a stem cell product for your treatment. Usually, the production takes up to 21 days.
DONOR CELLSAccording to the doctor's prescription, the biotechnologist will select a ready-made and pre-tested sample of donor cells from our cryobank in the required quantity. In this case, cell injection can happen immediately after diagnosis and drug preparation.

5

Start of treatment

The first visit to the clinic to confirm the diagnosis includes preliminary diagnosis, analysis, and examination (ultrasound of the thyroid gland, ultrasound of the pelvic organs, ultrasound of the abdominal cavity, ECG, diagnosis of the affected target organs).

6

Pharmacological therapy

Based on the diagnostic results, your doctor will prescribe metabolic therapy to improve the functioning of the affected tissues. The doctor will also prepare you for cell therapy with the help of intravenous infusion, intramuscular injections, and correction of sugar levels (in case of severe disorders).

7

Injection of the cellular product, the regeneration phase

The injection of the cellular product is most often performed with intravenous administration. Perilymphatic administration, which provides stabilization for a longer period of action of the cellular material, is offered, too. Additionally, the administration to the affected organs takes place.
The doctor will choose the method of administration of the cellular drug specifically for you. The number of injections will depend on the degree of morbidity — usually from 2 to 5 injections, on average 3.
Depending on the doctor's recommendations and the course of the disease, re-administration may be prescribed. If the patient has stabilized and is compensated for the next few years, there is no need for an additional injection. Still, for those who return decompensated, the cell drug's re-injections are prescribed regularly, depending on the situation.

8

Medical assessment report and weakening of the basic treatment 

You will be provided with a medical assessment report that states the diagnosis, the examination results (clinical, laboratory, and instrumental), the treatment process, and further recommendations. The doctor will examine you, select the necessary treatment, or adjust the one prescribed to you at the time of arrival at the clinic.

9

Keeping in touch

Throughout the program, you will have a personal manager who will ensure the best communication between you and the clinic. After treatment, our patients are advised to maintain contact with us. We'll ask you to fill out a questionnaire in 3 and 6 months after the treatment to evaluate the progress and answer all questions.

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Scientific evidence

More than 70 clinical trials have been registered to evaluate the safety and efficacy of stem cell-based treatment for type 2 diabetes.
The most common types of stem cells undergoing clinical trials for the treatment of type 2 diabetes are bone marrow mononuclear cells, bone marrow mesenchymal stem cells, umbilical cord mesenchymal stem cells, and adipose tissue mesenchymal stem cells.
The results of numerous studies have shown that the use of MSCs in type 2 diabetes is:
 safe — no serious side effects; effective.
The reasons why the use of MSCs have been proven effective:
either refusing insulin injections whatsoever or reduced need for insulin by more than 50%; decreased glycosylated hemoglobin (HbA1C), indicating normalization of blood sugar; decreased levels of C-reactive protein, indicating a decrease in inflammation, a key driver of type 2 diabetes; improved pancreatic function; long-lasting positive effects observed for 1-3 years.
Mechanisms underlying the use of MSCs in the treatment of diabetes:
MSCs improve pancreas functions by preserving β-cell from apoptosis, promoting islet vascularization, and reducing inflammation;MSCs reduce insulin resistance of peripheral tissues by reducing the level of inflammatory cytokines;MSCs support liver function by boosting glucose metabolism in the liver.
More information about the study can be found in the following publications:
1. Yazhen Zhang, Wenyi Chen, Bing Feng, et al. The Clinical Efficacy and Safety of Stem Cell Therapy for Diabetes Mellitus: A Systematic Review and Meta-Analysis[J]. Aging and disease, 2020, 11(1): 141-153. http://www.aginganddisease.org/EN/10.14336/AD.2019.0421 2. Qi, Y., Ma, J., Li, S. et al. Applicability of adipose-derived mesenchymal stem cells in treatment of patients with type 2 diabetes. Stem Cell Res Ther 10, 274, 2019. https://doi.org/10.1186/s13287-019-1362-2

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FAQ

  • Will cell therapy help me cure diabetes forever?

    Unfortunately, no. The use of stem cells will improve your overall condition, relieve insulin dependency, and eliminate the symptoms that accompany the disease. But impaired insulin perception by pancreatic cells is a systematic problem that has genetic factors.

  • Can I give up the diet after cell therapy?

    No, you can't. The diet will be eased if your condition improves, but the diet is mandatory, just like other doctor's recommendations. Diet and a healthy lifestyle are crucial conditions for a successful treatment.

  • Am I guaranteed to stop insulin injections after treatment?

    It depends on your condition. Before starting the program, the doctor will make an individual prognosis of the effectiveness of the treatment. Then you will decide on the relevance of therapy for you.

  • Will my vision, vessel state, libido, body odor improve?

    Yes. Cell therapy aims to both regenerate the pancreas itself and repair all sugar-damaged tissues. All of the above pathologies (target organs) will improve after treatment.

  • Will it be necessary to regularly renew the course of therapy?

    The course of treatment should last as long as needed. There are no prescriptions to use stem cell therapy regularly. Still, if the condition is critical (i.e., many target organs affected, vision problems, erectile dysfunction, trophic ulcers), you may be prescribed additional therapy.

  • Does cell therapy exclude the use of drugs or insulin?

    No, it does not. Stem cells are not a panacea and are prescribed comprehensively. Before starting treatment, the patient's condition should be decompensated and sugar levels stabilized. The body must create a favorable environment for maximal survival of stem cells and their effective functioning. Insulin discontinuation will occur gradually as pancreatic cells recover.