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Autism


Neural crest-derived multipotent stem cells can form new neurons and glial cells.This is what gives a child a chance for a better life.

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Stem cells are the new way to better communication!

Stem cell therapy helps develop the speech center and boost the functioning of the centers responsible for the child's socialization, which in term improves communication skills and reduces anxiety and aggression.

Roman Sulik, MD, coordinator of cell therapy programs, neurologist of the highest qualification category

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Autism treatment 

Autism is a common name for diseases that are related to autism spectrum disorders. Autism in children is:
atypical;
normal;
high-performance and others.

The causes of autism are almost always unknown. Each of these diseases has its mechanism. Therefore, all children with autism are unique.
What can be expected from therapy?
1. Development of the speech center.
2. Development of centers responsible for the socialization of the child.
3. Improving her communication skills.
4. Reducing the child's anxiety and aggression.

Treatment of autism in children depends on the age and stage of development of the child. The main therapy is the introduction of multipotent stem cells derived from the neural crest. Administration may be intravenous, local to the perilymphatic and pericranial areas, or endonasal.
Before each procedure, specific inhalation therapy is performed.

The directed action of cellular material on the necessary areas of the brain stimulates the centers that are responsible for socialization and the development of communication skills.

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Indications for the treatment of autism by stem cells

Indication:
This treatment is indicated for patients over 3 y.o. diagnosed with typical or atypical autism.
Contraindication:
● cancer, or its history in the last 5 years.



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How to treat autism spectrum disorders with stem cells?

Stem cells derived from the neural crest are best suited for the treatment of autism. They can modulate the receptive apparatus of brain cells. Improvements are observed due to:
correction of receptor sensitivity;
improving the functions of brain structures such as the amygdala, hippocampus, and prefrontal cortex, and their interaction with each other.

It helps children develop normal skills and reflections, improve socio-communicative abilities and reactions to external stimuli.

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The treatment process

  • 1. Consultation with a manager

    Contact our managers. At this step, we gather your medical information and confirm the diagnosis. After that, we'll arrange a free online or offline consultation with a doctor.

  • 2. Consultation with a doctor 

    A personal consultation with a doctor is an excellent opportunity for you to find out all details of the program and get an individual prognosis. All the medical information you provide will be carefully reviewed so that you get the most effective treatment. The procedures take place in our clinical institutions in Kyiv, Ukraine.
    The course of the treatment is developed individually and lasts for 3 days or more.

  • 3. Checkup

    During the checkup, the doctor assesses your readiness for cell therapy. If the assessment is positive, biological materials are taken. Depending on your doctor's recommendations, you may be prescribed your own* or donor stem cells.

    * If you are prescribed the treatment with your own cells, you will have an ear punch biopsy performed under anesthesia in an operating room. The procedure lasts for 15 minutes. The punch depth is up to 4 mm, and the diameter is up to 3 mm.

  • 4. Preparation of the stem cell product

    OWN CELLSAfter the biomaterials are collected, our team of biotechnologists will prepare a therapeutic dose of stem cells. In our laboratory, we will select stem cells from your sample, grow the required number of cells, test them, then create a stem cell product for your treatment. Usually, the production takes up to 21 days.
    DONOR CELLSAccording to the doctor's prescription, the biotechnologist will select a ready-made and pre-tested sample of donor cells from our cryobank in the required quantity. In this case, cell injection can happen immediately after diagnosis and drug preparation.

  • 5. Start of treatment

    During your first visit to the clinic, you will consult with a doctor, then have an instrumental, clinical, and laboratory checkup.

    Based on the results of the checkup, the doctor may prescribe drug therapy.

  • 6. Injection of the cellular product, the regeneration phase

    The doctor may prescribe intravenous, local, and endonasal administration of the stem cells. Depending on the child’s age and development, the procedure can be repeated from 1 to 3 times.

  • 7. Medical assessment report and weakening of the basic treatment 

    You will be provided with a medical assessment report that states the diagnosis, the examination results (clinical, laboratory, and instrumental), the treatment process, and further recommendations. The doctor will examine you, select the necessary treatment, or adjust the one prescribed to you at the time of arrival at the clinic.

  • 8. Keeping in touch

    The first results can be observed within 2 weeks. You will see the improvement of the regenerative processes in the body in 3-6 months after treatment.

    Throughout the program, you will have a personal manager who will ensure the best communication between you and the clinic. After treatment, our patients are advised to maintain contact with us. We'll ask you to fill out a questionnaire in 3 and 6 months after the treatment to evaluate the progress and answer all questions.

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Scientific evidence

The use of cell therapy, in particular MSCs, in overcoming autism spectrum disorders (ASD) is based on two factors: first, a direct connection between the level of inflammation and the severity of behavioral disorders in children with ASD, and secondly, the ability of MSCs to suppress immune cells. MSCs can block the excessive activation of CD8 + and CD4 + T lymphocytes, NK cells by inhibiting the secretion of pro-inflammatory cytokines TNF-α, INF-ɣ and promote an increase in anti-inflammatory cytokines such as IL-10. By suppressing inflammatory processes in children with ASD, it is potentially possible to improve social and behavioral indicators.
The most powerful stem cells for ASD treatment are:
MSCs of the umbilical cord; MSCs of bone marrow/adipose tissue.
Published results of cell-based therapy in ASD showed:
no serious side effects; improved cognitive and social performance; improved blood supply to the brain; improved state of the immune system.
More details:1. Alok Sharma, Nandini Gokulchandran, Hemangi Sane, Anjana Nagrajan, Amruta Paranjape, Pooja Kulkarni, Akshata Shetty, Priti Mishra, Mrudula Kali, Hema Biju, Prerna Badhe, "Autologous Bone Marrow Mononuclear Cell Therapy for Autism: An Open-Label Proof of Concept Study", Stem Cells International, vol. 2013, Article ID 623875, 13 pages, 2013. https://doi.org/10.1155/2013/6238752. Lv, Y., Zhang, Y., Liu, M. et al. Transplantation of human cord blood mononuclear cells and umbilical cord-derived mesenchymal stem cells in autism. J Transl Med 11, 196, 2013. https://doi.org/10.1186/1479-5876-11-1963. Dawson G. et al. Autologous Cord Blood Infusions Are Safe and Feasible in Young Children with Autism Spectrum Disorder: Results of a Single-Center Phase I Open-Label Trial, 2017. Stem Cells Translation Medicine. http://dx.doi.org/10.1002/sctm.16-0474