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Diabetic foot


It is possible to improve foot tissue by boosting innervation and blood supply with the help of stem cells.

Safe stem cells

Stem cells take care of the health of your feet!

The effectiveness of such treatment can vary depending on the degree of the patient's decompensation and is between 40 and 60%.

Roman Sulik, MD, coordinator of cell therapy programs, neurologist of the highest qualification category, and Candidate of Medical Sciences.

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Tactics of diabetic foot treatment

The cause of diabetic foot is insufficient innervation and blood supply of the most distant tissues in patients with diabetes.
Thus, the main treatment tactics are the restoration of peripheral vessels, peripheral nerves, and the impaired tissue, in our case, the foot.
Doctors and biotechnologists at GOOD CELLS offer treatment of diabetic foot with mesenchymal stem cells from adipose tissue (MSCs of adipose tissue), which improve the course of diabetes itself, help restore vascular endothelium and enhance metabolism in the foot. Usage of the neural crest-derived multipotent stem cells could help restore the nerve tissue of the foot.

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For whom is this treatment?

Indications:
This treatment is indicated for patients over 18 y.o. with confirmed type 2 diabetes mellitus complicated by diabetic foot.
Contraindications:
cancer, or its history in the last 5 years; pregnancy; mental disorders and psychological instability; alcohol and drug addiction.

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What to expect from treatment?

As a result of the treatment, you will feel an improvement in the disease manifestation:
reduction of foot pain; reduction of edema; reduction of trophic disorders, such as skin discoloration; reduction of the need for drugs against diabetes because the cells can stabilize metabolic processes both locally and in all tissues of the body.
The results of treatment lie in the restoration of blood supply and recovery of nervous tissue.

Safe stem cells

The treatment process

1

Consultation with a manager

Contact our managers with no obligations on your side. At this step, we gather your medical information and confirm the diagnosis. After that, we'll arrange a free online or offline consultation with a doctor.

2

Online/offline consultation with a doctor 

A personal consultation with a doctor is an excellent opportunity for you to find out all details of the program and get an individual prognosis. All the medical information you provide will be carefully reviewed so that you get the most effective treatment. The procedures take place in our clinical institutions in Kyiv, Ukraine. The course of the treatment is developed individually and lasts between 1 and 7 days.

3

Checkup

During the checkup, the doctor assesses your readiness for cell therapy. If the assessment is positive, biological materials are taken. Depending on your doctor's recommendations, you may be prescribed your own* or donor stem cells.
*If you are prescribed the treatment with your own cells, you will have an ear punch biopsy performed under anesthesia in an operating room. The procedure lasts for 15 minutes. The punch depth is up to 4 mm, and the diameter is up to 3 mm.

4

Preparation of the stem cell product

OWN CELLSAfter the biomaterials are collected, our team of biotechnologists will prepare a therapeutic dose of stem cells. In our laboratory, we will select stem cells from your sample, grow the required number of cells, test them, then create a stem cell product for your treatment. Usually, the production takes up to 21 days.
DONOR CELLSAccording to the doctor's prescription, the biotechnologist will select a ready-made and pre-tested sample of donor cells from our cryobank in the required quantity. In this case, cell injection can happen immediately after diagnosis and drug preparation.

5

Start of treatment

The first visit to the clinic to confirm the diagnosis includes preliminary diagnosis, analysis, and examination (ultrasound of the thyroid gland, ultrasound of the pelvic organs, ultrasound of the abdominal cavity, ECG, diagnosis of the affected target organs).

6

Pharmacological therapy

Based on the diagnostic results, your doctor will prescribe metabolic therapy to improve the functioning of the affected tissues. The doctor will also prepare you for cell therapy with the help of intravenous infusion, intramuscular injections, and correction of sugar levels (in case of severe disorders).

7

Injection of the cellular product, the regeneration phase

As part of the treatment, you will receive intravenous cell therapy, as well as a local injection into the foot and leg. Depending on the course of the disease, additional areas may be involved, such as the abdomen.

8

Medical assessment report and weakening of the basic treatment 

You will be provided with a medical assessment report that states the diagnosis, the examination results (clinical, laboratory, and instrumental), the treatment process, and further recommendations. The doctor will examine you, select the necessary treatment, or adjust the one prescribed to you at the time of arrival at the clinic.

9

Keeping in touch

Throughout the program, you will have a personal manager who will ensure the best communication between you and the clinic. After treatment, our patients are advised to maintain contact with us. We'll ask you to fill out a questionnaire in 3 and 6 months after the treatment to evaluate the progress and answer all questions.

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Feedback from our patients

Find out why patients choose an innovative method of treating diabetic foot from GOOD CELLS!

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Safe stem cells

Scientific evidence

In addition to our own practical experience in treating ulcers that occur during the diabetes progression, numerous foreign studies have shown the usefulness of using cellular products in the treatment of the diabetic foot. The most commonly used cells are bone marrow MSCs, placental MSCs, umbilical cord MSCs, MSC derivatives such as conditioning medium, exosomes. In most of the studied cases, the use of cellular products led to:
 complete healing of ulcers, while traditional treatment allowed to reduce the area of ​​the wound by approximately 70%; preservation of foot function after transplantation; restoration of blood supply to the limb;the disappearance of pain at rest.
There were no complications throughout the observation period.
More about the results of the research are in the links below:
1. Becerra-Bayona S.M., Solarte-David V.A., Sossa S.L. et al. Mesenchymal stem cells derivatives as a novel and potential therapeutic approach to treat diabetic foot ulcers // Endocrinology, Diabets&Metabolism, 2020. https://doi.org/10.1530/EDM-19-01642. Maksimiva N, et al. Early passage autologous mesenchymal stromal cells accelerate diabetic wound re-epithelialization: A clinical case study // CCytotherapy 2017. https://doi.org/10.1016/j.jcyt.2017.08.0173. Debin Lu et al. Autologous transplantation of bone marrow mesenchymal stem cells on diabetic patients with lower limb ischemia // J of Medical Colleges of PLA, 2008. https://doi.org/10.1016/S1000-1948(08)60031-3