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Backache. Intervertebral disc herniation and facet joint syndrome.

Cell therapy can be a solution to the back pain.

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  3. Backache. Intervertebral disc herniation and facet joint syndrome.

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Cell therapy for back pain in GOOD CELLS

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Back pain treatment 

The human spine not only helps to keep the back straight but also primarily protects the spinal cord, which performs vital functions, including reflex and conduction. Therefore, it is very important to protect the spine. During life, he receives a considerable load, so everyone sometimes has a sore back. With age, back pain becomes more common. The most common is low back pain.
Intervertebral disc herniation and facet syndrome are the most common manifestations of a depleted spine. Each case is accompanied by back pain and sometimes leads to limited movement.
GOOD CELLS offers cell therapy to reduce pain and improve musculoskeletal function. To do this, your doctor may prescribe a local injection of mesenchymal stem cells from adipose tissue (MSCs of adipose tissue).
In about 87% of patients, the volume of movement is restored and in 73% of cases, the pain is reduced.

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Indication for stem cell therapy

This treatment is indicated for patients over 18 y.o. with diagnosed intervertebral disc herniation or facet joint syndrome.
oncological diseases or their presence in the anamnesis for the last five years; pregnancy; mental disorders; alcohol and drug addiction.

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How do stem cells help?

Mesenchymal stem cells from adipose tissue have a wide range of action. Many studies and our observations show that these cells are able to differentiate into connective tissue, promote tissue regeneration, neovascularization of affected tissues and inhibit the inflammatory process.
The protocol for the extraction of MSCs from adipose tissue is standardized and used worldwide.

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The treatment process

  • 1. Consultation with a manager

    Contact our managers. At this step, we gather your medical information and confirm the diagnosis. After that, we'll arrange a free online or offline consultation with a doctor.

  • 2. Consultation with a doctor 

    A personal consultation with a doctor is an opportunity for you to find out all details of the program and get an individual prognosis. All the medical information you provide will be carefully reviewed so that you get the most effective treatment. The procedures take place in our clinical institutions in Kyiv, Ukraine.
    The course of the treatment is developed individually and lasts 4 days or more.

  • 3. Checkup

    During the checkup, the doctor assesses your readiness for cell therapy. If the assessment is positive, biological materials are taken. Depending on your doctor's recommendations, you may be prescribed your own* or donor stem cells.

    * If you are prescribed the treatment with your own cells, you will have an ear punch biopsy performed under anesthesia in an operating room. The procedure lasts for 15 minutes. The punch depth is up to 4 mm, and the diameter is up to 3 mm.

  • 4. Preparation of the stem cell product

    OWN CELLSAfter the biomaterials are collected, our team of biotechnologists will prepare a therapeutic dose of stem cells. In our laboratory, we will select stem cells from your sample, grow the required number of cells, test them, then create a stem cell product for your treatment. Usually, the production takes up to 21 days.
    DONOR CELLSAccording to the doctor's prescription, the biotechnologist will select a ready-made and pre-tested sample of donor cells from our cryobank in the required quantity. In this case, cell injection can happen immediately after diagnosis and drug preparation.

  • 5. Start of treatment

    During your first visit to the clinic, you will consult with a doctor, then have an instrumental (MRI or X-ray), clinical, and laboratory checkup.

  • 6. Injection of the cellular product, the regeneration phase

    As part of treatment, the doctor may prescribe local introduction of the cellular product.

  • 7. Medical report and reducing of the basic treatment

    You will be provided with a medical assessment report that states the diagnosis, the examination results (clinical, laboratory, and instrumental), the treatment process, and further recommendations. The doctor will examine you, select the necessary treatment, or adjust the one prescribed to you at the time of arrival at the clinic.

  • 8. Keeping in touch

    The main results can be observed within 6 months after treatment. You will see the improvement of the regenerative processes in the body.

    Throughout the program, you will have a personal manager who will ensure the best communication between you and the clinic. After treatment, our patients are advised to maintain contact with us. We'll ask you to fill out a questionnaire in 3 and 6 months after the treatment to evaluate the progress and answer all questions.

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Scientific evidence

Intervertebral disc degeneration is considered to be one of the main causes of low back pain, contributing to other disc pathologies, such as disc herniation, spinal canal stenosis, or facet joint syndrome.The avascularity of the intervertebral discs is an obstacle to the regeneration of the body's forces, due to the migration of SC from other depots.Tissue-specific progenitor cells have been identified in the intervertebral discs and can be targeted for regeneration.The results of preclinical studies have shown that the addition of functional cells with exogenous SC has a regenerative effect in the degeneration of intervertebral discs.
The use of MSCs in the treatment of intervertebral disc degeneration is based on data from preclinical studies, namely:
MSCs can survive after transplantation and differentiate into chondrocytes; MSCs stimulate the restoration of extracellular matrix protein synthesis, including type II collagen; MSCs, having immunosuppressive properties, help reduce inflammation and stop further death of functional cells of the disc.
A pilot study by Centeno et al. (2017) showed the results of the use of autologous MSCs in intervertebral discs. Thirty-three patients with lower back pain and disc degeneration with diagnosed posterior disc bulge on magnetic resonance imaging were included in the study. Autologous MSCs of the bone marrow were used for treatment.The study did not reveal any serious side effects associated with MSC transplantation. Numerical pain scores (NPS) relative to baseline decreased significantly after 3, 36, 48, 60, and 72 months after treatment. Twenty patients who underwent MRI after treatment had a reduction in the size of the bulge of the disc, the average size reduction – by 23% after treatment.
Original publication:Centeno, C., Markle, J., Dodson, E. et al. Treatment of lumbar degenerative disc disease-associated radicular pain with culture-expanded autologous mesenchymal stem cells: a pilot study on safety and efficacy. J Transl Med 15, 197, 2017.

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  • Will this treatment relieve the pain immediately?

    Yes, you will feel relief immediately after the procedure.

  • Can I play sports after treatment?

    Moderate physical activity will be required. This will improve back muscles and blood circulation, which is essential for the effective results of stem cell transplantation.

  • Is it possible to restore the functionality of the spine after injuries with the help of stem cells?

    We can't be sure. Stem cell therapy results depend on the type of damage, the amount of damaged tissue, the patient's age, etc. Today, some technologies allow you to restore nerve fibers, but they are based solely on the patient's natural ability to regenerate tissues.

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Do you have any questions left?

Please contact us, our managers are always ready to answer your questions. Consultation by phone is completely free and does not oblige you to anything.We will be happy to provide you with comprehensive information so that you could make the right choice!