A new policy on the origin of cells in a three-component graft for patients with ENS

03.08.2021

Our specialists have been studying and developing a new biotechnological material for a long time, which is suitable for replacing the lost volume of the nasal sinuses in empty nose syndrome (ENS).

Biotechnological product to replace the lost volume in ENS

After studying many scientific materials, biotechnologists at Good Cells has determined the graft formula:● methylcellulose solution;● allogeneic cell-free lyophilized adipose tissue matrix;● autologous MSCs of adipose tissue.
After successful animal studies, we began using the material in patients with nasal tissue deficiency. Our doctors and scientists closely monitor these patients' health and do everything to improve the effectiveness of treatment.
Observations have shown that autologous mesenchymal stem cells are the best variant of the graft’s cellular component.

Allogeneic VS Autologous cells

The main therapeutic potential of MSCs is realized through the paracrine pathway due to the production of a number of biologically active substances: cytokines, chemokines, growth factors, and so on. When administered cells systemically (intravenously) or locally (intra-articularly, subcutaneously, under the mucous like), there is no significant difference in the selection cells (autologous or allogeneic).
However, when working with tissue-engineered constructs and grafts, another stem cell effect is more important for volume replacement - direct differentiation, i.e. the transformation of SC into the missing cell type.The patient's own cells are better differentiated due to the peculiarities of biochemical processes. Therefore, in such cases, only this type of cell should be used.
Another important advantage of autologous cells is that grafts using them are not lysed that quickly and are more stable to the patient's immune system.

What cell types are used in the treatment of ENS in GOOD CELLS?

Most patients require 2 types of stem cells:
1. MSCs of adipose tissue improve trophic and mucosal functions and replace lost volume with complete connective tissue.2. Neural crest-derived stem cells restore the receptor apparatus of the nasal sinuses. It is necessary to improve the sensitivity function of the nose (smell and feeling of airflow).
Patients undergo minimally invasive punch biopsy to obtain populations of these cell types.
The cells obtained after the procedure can be stored in his own master bank within the bioinsurance program on the patient's request. Then the patient will be able to repeatedly use not only MSC of adipose tissue and neural crest-derived stem cells but also fibroblasts. The latter are used to maintain the elasticity and youth of the skin. At the same time, repeated biopsies do not need.

To sum up

Based on theoretical knowledge and observations during the treatment process of the first patients, we believe that the use of autologous stem cells is more effective. Therefore, we will offer using this type of cells with the three-component graft within treatment programs in the future.

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